A suburban couple's ordinary lives are rocked by the sudden discovery that their children possess mutant powers. Forced to go on the run from a hostile government, the family joins up with an underground network of mutants and must fight to survive.

Thanks to a Japanese scientist's invention of synthetic blood, vampires have progressed overnight from legendary monsters to fellow citizens. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides. But in the small Louisiana town of Bon Temps, the jury is still out.

In early 19th-century France, the Marquis de Sade is confined to an asylum where his forbidden writings continue to circulate beyond its walls. As the authorities tighten control, a clash unfolds between the Marquis’ unyielding imagination, the reformist ideals of the Abbé in charge, and the repressive measures of a doctor sent to silence him. Desire, power, and censorship collide in a battle over freedom of expression.