When an insidious supernatural force edges its way into a seemingly straightforward investigation into the gruesome murder of a young boy, it leads a seasoned cop and an unorthodox investigator to question everything they believe in.

Set in downtown New York in 1900, 'The Knick' is centered on the Knickerbocker Hospital and its staff, notably Dr. John Thackery, the hospital's brilliant chief surgeon who pushes medicine's boundaries, pioneering new procedures despite a severe drug addiction.