A suburban couple's ordinary lives are rocked by the sudden discovery that their children possess mutant powers. Forced to go on the run from a hostile government, the family joins up with an underground network of mutants and must fight to survive.

Rip Wheeler and Beth Dutton gamble everything on a new life in South Texas, but the promise of building a future far from the ghosts of Yellowstone quickly collides with brutal new realities and a rival ranch that will stop at nothing to protect its empire.