Iwakura Mitsumi, a tenacious country girl, prepares for high school in the big city. She meets the handsome Shima Sousuke, whose easygoing ways help her adapt in the real world.

Akira Fudo learns from his best friend Ryo Asuka that demons will revive and reclaim the world from humans. With humans hopeless against this threat, Ryo suggests combining with a demon. With this, Akira becomes Devilman, a being with the power of demon but with a human heart.