Thanks to a Japanese scientist's invention of synthetic blood, vampires have progressed overnight from legendary monsters to fellow citizens. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides. But in the small Louisiana town of Bon Temps, the jury is still out.

Based on the true story of Grace Marks, a housemaid and immigrant from Ireland who was imprisoned in 1843, perhaps wrongly, for the murder of her employer Thomas Kinnear. Grace claims to have no memory of the murder yet the facts are irrefutable. A decade after, Dr. Simon Jordan tries to help Grace recall her past.